By Robert Pruitt, Healthday Reporter
MONDAY, January 25, 2021 (HealthDay News) – Here is a reason why past or present smoking may bother you if you are battling breast cancer: new research suggests nicotine promotes the spread of disease in your lungs is.
Smoking suggests that there is an increased risk of spreading breast cancer, which reduces the survival rate by one-third during diagnosis. But the role of nicotine in the spread of breast cancer to the lungs has been less clear.
To find out more, the researchers studied about 1,100 breast cancer patients. They found that current smokers and former smokers never had higher rates of breast cancer than those who spread to the lungs.
In a study of mice, researchers found that the nicotine foster that spreads. And this was true even after not being exposed to nicotine for 30 days.
According to the team at the Wake Forest School of Medicine in Winston-Salem, NC, there is a suggestion that there is a risk for pre-smoker breast cancer patients.
His findings were published online in the journal on 20 January Nature communication.
“Our data show that exposure to nicotine creates an environment in the lungs that is ripe for metastatic development,” said study researcher Kaunusuke Watabe, professor of cancer biology at Wake Forest.
Prolonged exposure to nicotine creates an “inflammatory microenvironment” in the lungs. It attracts immune cells called neutrophils, which release a protein that encourages the spread of cancer, the authors explained.
They also found that salidroside is a natural compound found in the plant Rhodiola Rasia, Blocks the formation of neutrophils.
Salidroside has anti-inflammatory, anti-cancer and anti-viral properties. Researchers found that the incidence of neutrophils and lung metastasis decreased significantly in mice. The results of animal studies may differ in humans.
“Based on these findings, breast cancer patients should choose smoking-avoidance programs that do not use nicotine-replacement products,” Wakeb said in a Wake Forest news release. “Furthermore, our findings suggest that saliroside may be a promising therapeutic drug to help prevent smoking-induced breast cancer lung metastasis, although more research is needed.”
Source: Wake Forest Baptist Health, news release, January 20, 2021
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